Dapoxetine (CAS: 119356-77-3) is a pharmaceutical intermediate belonging to the class of selective serotonin reuptake inhibitors (SSRIs). It appears as a white to off-white crystalline powder, features a stable molecular structure, and possesses well-defined, measurable physicochemical properties. Produced using established synthesis and purification processes, this raw material is widely used in early-stage formulation research, the preparation of laboratory reference standards, pharmacological benchmarking, and the development of pharmaceutical intermediates. Its consistent batch purity and solubility characteristics meet the diverse R&D needs for downstream solid dosage forms and formulation process development.
As a classic active ingredient for research in the field of pharmaceutical intermediates, Dapoxetine API powder is produced under strict control of the entire manufacturing and purification process. Product purity is verified via High-Performance Liquid Chromatography (HPLC), and a corresponding quality inspection report is provided for every batch. We offer flexible supply options-ranging from small samples to large-scale batches-providing stable and reliable Dapoxetine raw material solutions to global pharmaceutical R&D organizations, chemical synthesis companies, and research institutes.
| Name | Dapoxetine |
| Alias | S-(+)-N,N-Dimethyl-α-[2-(naphthyloxy)ethyl]benzylamine |
| Chemical formula | C21H23NO |
| Molecular weight | 305.413 [2] |
| CAS Registry Number |
119356-77-3 |
| Boiling point | 454.4 ℃ |
| Density |
1.081 g/cm³ |
| Appearance | White to off-white crystalline powder |
| Flash point | 132.6 ℃ |
| Exact mass |
305.17800 |
|
PSA |
12.47000 |
| Molecular structure diagram |  |
| Refractive index | 1.607 |
Mechanism of Action of Dapoxetine
The pharmacological action of dapoxetine centers on the modulation of central serotonergic neurotransmission; the specific mechanisms are as follows:
Dapoxetine acts by competitively inhibiting the serotonin transporter (SERT) on the presynaptic membrane, thereby reducing serotonin reuptake and increasing serotonin concentrations within the synaptic cleft. Serotonin is a key neurotransmitter regulating the ejaculatory reflex; elevated levels inhibit excessive excitability in supraspinal central nervous system structures-such as the hypothalamus and cerebral cortex-and delay the transmission of the ejaculatory impulse, thereby prolonging the ejaculatory latency period.
Studies indicate that dapoxetine primarily acts at the supraspinal level of the central nervous system (e.g., the cerebral cortex and hypothalamus). Animal experiments demonstrate that dapoxetine significantly inhibits ejaculatory responses triggered by cortical stimulation but has no significant effect on the sacral spinal ejaculatory center. Research on rats has further revealed that specific brain networks-including the prefrontal cortex and amygdala-are activated during ejaculation; dapoxetine reduces neuronal activity within these networks, thereby diminishing the "urgency" associated with ejaculation.
Dapoxetine's pharmacokinetic profile is key to its suitability for on-demand treatment:
Rapid absorption: Peak plasma concentration is reached 1.3–1.4 hours after oral administration, ensuring a rapid onset of action;
Rapid elimination: It has a short half-life (1.5–1.6 hours) and does not accumulate with repeated dosing, thereby avoiding adverse effects associated with long-term use;
Good tolerability: Clinical studies show that the discontinuation rate due to adverse effects is less than 5%, and abrupt cessation does not result in anxiety or withdrawal syndrome.
Dosage and Administration
The recommended initial dose is 30 mg (1 tablet), suitable for most patients; if the 30 mg dose is ineffective and no severe adverse reactions occur, the dose may be increased to 60 mg (maximum dose). Do not exceed one dose within a 24-hour period.
Dosage adjustments for special populations:
Hepatic impairment: Contraindicated in severe hepatic impairment (Child-Pugh Class C); avoid use in moderate hepatic impairment (Child-Pugh Class B); standard dosage may be used for mild hepatic impairment (Child-Pugh Class A).
Renal impairment: Contraindicated in severe renal impairment (creatinine clearance <30 mL/min); standard dosage may be used for mild to moderate renal impairment (creatinine clearance 30–89 mL/min), but renal function must be monitored.
Elderly patients: Use with caution in patients over 65 years of age; the starting dose is 30 mg, and adverse reactions should be closely monitored.
Minors: Contraindicated in patients under 18 years of age.
Packaging and Delivery
Packaging Specifications
Small-batch packaging: 1kg, 5kg, or 10kg sealed packs using aluminum foil bags with thickened, waterproof inner liners.
Bulk packaging: 25kg standard export-grade cardboard drums, kraft paper drums, or plastic drums-sturdy, pressure-resistant, and deformation-resistant.
All packaging features double-layer sealing to prevent moisture, clumping, leakage, and contamination.
Shipping channels
Supports delivery via DHL, FedEx, UPS, EMS, as well as sea, air, and multi-channel shipping;
Reliable freight forwarding partnerships enable end-to-end tracking of logistics, customs clearance, and release status, with timely updates provided to the customer.
Payment methods: Wire Transfer, Western Union, MoneyGram, Letter of Credit.
Delivery lead time
Standard stock items: Shipped within 24–48 hours of payment confirmation.
Customized repackaging/special specifications: Shipment arranged within 3–7 business days.
High-volume orders during peak seasons are scheduled in advance to ensure on-time delivery.
After-Sales Support
Pre-sales Service
Technical Consultation: A professional team provides product specifications, application solutions, and compliance guidance, while addressing inquiries related to R&D and production.
Sample Assurance: Small samples are available for testing prior to placing an order (shipping costs borne by the customer); orders may be cancelled unconditionally if the sample specifications do not match those of the bulk shipment.
In-sales Service
Order Tracking: Real-time synchronization of production progress, shipment status, and logistics information, accessible to customers at any time.
Quality Communication: Re-inspection and verification of each batch prior to shipment, with timely feedback on test results to ensure product quality.
Customization: Adjustment of purity, packaging, and documentation based on customer needs to meet specific order requirements.
After-sales Service
Quality Assurance: Free returns and exchanges are available for any quality issues within 7 days of delivery, with shipping costs covered by us.
Technical Support: Ongoing technical guidance provided, including formula optimization, process adjustments, and compliance declarations.
Long-term Partnership: Establishment of customer profiles to provide priority supply, preferential pricing, and dedicated service, ensuring a stable, long-term partnership.
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