This high-purity Orlistat raw material powder (CAS: 96829-58-2) is an off-white crystalline powder produced via precision synthesis and serves as a key ingredient for weight-management dietary supplements. It acts locally within the gastrointestinal tract by inhibiting lipase activity, thereby preventing the breakdown of dietary triglycerides into absorbable fatty acids; the undigested fat is subsequently excreted from the body. As it does not enter the systemic circulation or affect the central nervous system, it avoids side effects such as increased appetite, heart palpitations, or insomnia, making it a widely used and safe ingredient in weight-loss products globally.
Production takes place in a sealed, Class 100,000 cleanroom environment, with comprehensive physicochemical and microbiological testing conducted in accordance with USP and EP standards. Every production batch is fully traceable, and all documentation required for export customs clearance and third-party testing can be provided, ensuring stable, long-term supply to overseas health supplement manufacturers.
What are the Key Highlights of Orlistat Raw Material Powder?
Functions exclusively within the digestive tract, reducing dietary fat absorption by nearly 30%. It minimizes fat accumulation during a normal diet without requiring strict calorie restriction or the forced limitation of staple foods, making it ideal for daily weight management formulations. Unlike appetite suppressants, it does not cause discomfort such as intense hunger or irritability.
Processed via targeted recrystallization, the powder features uniform, loose particles and stable flowability, ensuring smooth operation on high-speed capsule filling lines without mold sticking or clogging. It performs well in dry granulation/direct compression processes, yielding tablets that are resistant to capping or crumbling. When stored in a sealed, cool, and dark environment, physicochemical properties remain stable for 24 months, and the product resists moisture absorption and clumping during long-distance ocean transport.
Utilizes a combined purification strategy involving chromatographic separation of crude synthetic product and multiple recrystallization steps. This effectively removes synthetic intermediates and heavy metal catalyst residues, maintaining an active ingredient content of 99% or higher. Residue levels comply with entry standards for dietary ingredients in Europe, the US, and Southeast Asia, allowing for direct use in compliant health supplement formulations.
Supports laboratory testing and validation with small-batch (1 kg) samples and offers standard packaging in 25 kg fiber drums for bulk orders. Long-term partners can sign price-lock agreements to hedge against cost increases caused by market fluctuations. Each shipment includes a Certificate of Analysis (COA) and HPLC chromatograms; we also assist with preparing inspection documentation and facilitate independent sampling and verification by overseas agencies.
Stable when combined with ingredients such as dietary fiber, plant extracts, calcium pyruvate, and L-carnitine hydrochloride; the mixture shows no signs of flocculation or degradation. It can be used to develop single-action weight loss products or "fat-burning plus fat-blocking" dual-action dietary supplements.
Product Benefits and Use Cases
Product Benefits
1. Inhibits intestinal lipase and blocks fat absorption
It specifically inhibits the activity of gastrointestinal lipase, preventing the breakdown of dietary triglycerides. Approximately 30% of ingested fat remains unabsorbed by the intestines and is excreted directly in the stool, thereby reducing caloric intake at the source and minimizing fat accumulation in the body.
2. Supports weight management and steadily reduces body fat
It allows for fat accumulation reduction without the need for forced dieting or meal restriction; simply maintaining a normal three-meal routine suffices. Long-term use can lead to gradual weight loss and a smaller waistline, making it ideal for overweight individuals looking to reduce body fat.
3. Reduces fat accumulation and improves abdominal obesity
It prevents excess fat from building up in the abdominal area and around internal organs. It is particularly effective against abdominal obesity, helping to firm up the physique and reduce unwanted fat deposits.
Practical Application Scenarios
1. Pre-meal fat-blocking capsules: Formulated with key ingredients typical of mainstream weight-loss capsules; taken before meals to inhibit dietary fat absorption.
2. Portable oral tablets: Available as standard swallowable or chewable tablets, designed for convenient, everyday weight management.
3. Compound-formula supplements: Blended with various fat-reducing ingredients to create comprehensive weight-management dietary products.
Basic Product Specifications
| Product Name | Orlistat |
| CAS No. | 96829-58-2 |
| Molecular Formula | C₂₉H₅₃NO₅ |
| Molecular Structure Diagram |  |
| Molecular Weight | 495.73 |
| Appearance | Off-white crystalline powder |
| Quality Standards (USP/EP Pharmacopoeia Grade) | |
| Assay | ≥99.0% |
| Water Content | ≤0.5% |
| Residue on Ignition | ≤0.1% |
| Heavy Metals | Pb ≤10 ppm, As ≤2 ppm, Cd ≤1 ppm, Hg ≤1 ppm |
| Related Substances | Single largest impurity ≤0.1%, Total impurities ≤0.5% |
| Microbiological Limits | Total aerobic microbial count ≤1000 CFU/g; Molds and yeasts ≤100 CFU/g; *Salmonella*, *E. coli*, and *Staphylococcus aureus* |
| Storage, Packaging, and Shelf Life | |
| Storage Conditions | Store in a sealed container protected from light in a cool, dry place; refrigerated storage at 2°C–8°C is recommended; keep away from high temperatures and humidity. |
| Shelf Life | 24 months when unopened and stored according to specifications. |
| Packaging Specifications | Samples in 1 kg or 5 kg vacuum-sealed aluminum foil bags; bulk quantities in 25 kg fiber drums with sealed PE inner liners. |
After-Sales Support
Pre-sales Service
Technical Consultation: A professional team provides product specifications, application solutions, and compliance guidance, while addressing inquiries related to R&D and production.
Sample Assurance: Small samples are available for testing prior to placing an order (shipping costs borne by the customer); orders may be cancelled unconditionally if the sample specifications do not match those of the bulk shipment.
In-sales Service
Order Tracking: Real-time synchronization of production progress, shipment status, and logistics information, accessible to customers at any time.
Quality Communication: Re-inspection and verification of each batch prior to shipment, with timely feedback on test results to ensure product quality.
Customization: Adjustment of purity, packaging, and documentation based on customer needs to meet specific order requirements.
After-sales Service
Quality Assurance: Free returns and exchanges are available for any quality issues within 7 days of delivery, with shipping costs covered by us.
Technical Support: Ongoing technical guidance provided, including formula optimization, process adjustments, and compliance declarations.
Long-term Partnership: Establishment of customer profiles to provide priority supply, preferential pricing, and dedicated service, ensuring a stable, long-term partnership.
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