Sibutramine raw material powder (CAS: 106650-56-0; commonly used in pharmaceutical applications as sibutramine hydrochloride monohydrate) is a classic centrally acting appetite suppressant used in research and development. It appears as a white crystalline powder with the molecular formula C17H26ClN·HCl·H2O and a molecular weight of 334.32. Its mechanism of action involves inhibiting the reuptake of serotonin, norepinephrine, and dopamine in the central nervous system, thereby enhancing satiety and reducing food intake while simultaneously promoting thermogenesis and fat burning. This product is a mainstream raw material sourced by international weight-loss pharmaceutical manufacturers and weight-management dietary supplement producers. It features high, stable purity (≥99%), strict impurity control, excellent batch-to-batch consistency, and good flowability, making it suitable for various manufacturing processes, including capsules, tablets, and functional health supplements. As a primary manufacturer, Guanqing offers a stable, long-term supply of in-stock material and provides comprehensive documentation-including COA, MSDS, analytical spectra, and customs clearance data-to support compliant global exports, serving as a reliable supply chain partner for overseas pharmaceutical companies and nutritional brands.
What are the Primary Functions of Sibutramine Raw Powder?
Core Mechanism of Action
It acts on the central nervous system by utilizing its active metabolites in the body to inhibit the reuptake of serotonin, norepinephrine, and dopamine in the brain, thereby increasing neurotransmitter concentrations in the synaptic cleft:
Appetite Suppression
It enhances the brain's sense of satiety and significantly reduces feelings of hunger, leading to a voluntary reduction in food intake and control over total caloric consumption-effectively curbing dietary calorie intake at the source.
Mild Increase in Thermogenesis and Energy Expenditure
It stimulates thermogenic metabolism, slightly raising basal energy expenditure, reducing fat accumulation, and aiding in the breakdown of excess fat.
Metabolic Regulation Support
It has historically been used for individuals with obesity complicated by hyperlipidemia or mild insulin resistance; weight loss achieved through its use can indirectly improve blood lipid and blood glucose markers.
Historical Efficacy Results
When combined with dietary control and exercise, continuous use can result in a weight loss of 4–8 kg over a period of 4–8 weeks.
Key Product Characteristics
Physicochemical Properties
Physical Form
Sibutramine hydrochloride monohydrate appears as a fine white crystalline powder. It is odorless with a slightly bitter taste and exhibits excellent flowability, making it easy to weigh, blend, and formulate into experimental solutions; it is well-suited for laboratory-scale trials and the preparation of reference samples.
Stability
It maintains stable physicochemical properties when stored in sealed containers at room temperature; it is resistant to deliquescence and oxidation, ensuring a long shelf life. It is sparingly soluble in methanol and ethanol but virtually insoluble in pure water, facilitating the screening of solvent systems for experiments.
Controlled Purity
High-grade material with HPLC purity ≥99%, single impurity ≤0.2%, and total impurities ≤1.0%. Levels of moisture, heavy metals, and residual solvents comply with ICH quality control standards for research-grade raw materials, ensuring good reproducibility of experimental data.
Flexible Packaging
Available in aluminum foil bags (1g/5g) for small samples and cardboard drums (1kg/25kg) for laboratory use, meeting the needs of both micro-scale experiments and large-batch research projects.
Basic Product Specifications
| Basic Chemical Parameters | |
| Generic Name | Sibutramine (Sibutramine hydrochloride monohydrate) |
| English Name | Sibutramine Hydrochloride Monohydrate |
| CAS Number | 106650-56-0 |
| Molecular Formula (Free Base) | C17H26ClN |
| Molecular Structure |  |
| Molecular Formula (Hydrochloride Hydrate) | \ce{C17H26ClN·HCl·H2O} |
| Molecular Weight | 334.32 |
| Chemical Class | Monoamine reuptake inhibitor |
| Physical Properties | |
| Appearance | White to off-white crystalline powder |
| Odor | No distinct odor; slightly bitter taste |
| Solubility | Sparingly soluble in methanol and ethanol; practically insoluble in water |
| Flowability | Good powder flowability; easy to weigh and blend |
| Melting Point | 193–195°C |
| Quality Control Specifications (HPLC Analysis) | |
| Assay (Purity) | ≥99.0% |
| Single Largest Impurity | ≤0.20% |
| Total Impurities | ≤1.00% |
| Water Content | ≤0.5% |
| Heavy Metals | ≤20 ppm |
| Residual Solvents | Complies with ICH limits |
| Storage and Packaging Parameters | |
| Storage Conditions | Sealed, protected from light, in a cool, dry place (ambient temperature ≤25°C) |
| Long-term Storage | Sealed and refrigerated at -20°C |
| Standard Shelf Life | 24 months |
Company Profile
Shandong Guanqing Food Ingredients Co., Ltd. is a modern foreign trade supply chain enterprise specializing in the R&D and export of high-end pharmaceutical APIs, weight management ingredients, male health ingredients, and functional food additives. Headquartered in Linyi, Shandong, and leveraging the advantages of a comprehensive chemical raw material industrial cluster, the company has long been dedicated to the global B2B export of fine chemicals and health ingredients.
Our product portfolio encompasses a full range of food-grade chemical raw materials-including APIs for weight loss, active ingredients for male health, sweeteners, thickeners, humectants, and polyols-serving industries such as pharmaceuticals, dietary supplements, functional foods, and cosmetics. We rigorously vet our upstream manufacturing sources; every batch undergoes high-standard quality inspections to ensure consistent purity and controlled impurity levels. We provide comprehensive documentation-including COAs, MSDS, analytical charts, and customs clearance materials-to meet the regulatory and formulation registration requirements of various countries.
Since our inception, we have adhered to the business philosophy of "Quality First, Reliable Delivery, and Compliant Export," serving pharmaceutical manufacturers, health supplement brands, research institutions, and traders worldwide. We accommodate everything from sample testing and small-scale trial orders to bulk tonnage shipments, utilizing a mature international logistics network to ensure stable delivery to markets across Europe, the Americas, Southeast Asia, the Middle East, and Africa.
After-Sales Support
Pre-sales Service
Technical Consultation: A professional team provides product specifications, application solutions, and regulatory guidance, while addressing inquiries related to R&D and production.
Sample Support: Small samples are available for testing prior to order placement (shipping costs borne by the customer); orders may be cancelled unconditionally if sample specifications do not match the bulk shipment.
In-sales Service
Order Tracking: Real-time updates on production progress, shipment status, and logistics information are available for customer inquiry at any time.
Quality Communication: Each batch undergoes re-inspection and verification before shipment, with test results promptly communicated to ensure product quality.
Customization: Purity levels, packaging, and documentation can be adjusted to meet specific customer requirements and personalized orders.
After-sales Service
Quality Guarantee: Free returns and exchanges are provided for any quality issues identified within 7 days of delivery, with shipping costs covered by us.
Technical Support: Ongoing technical guidance is offered, including formula optimization, process adjustments, and regulatory compliance statements.
Long-term Partnership: We maintain customer profiles and offer priority supply, preferential pricing, and dedicated service to ensure a stable, long-term partnership.
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