We are launching a new product: Semaglutide API powder (CAS: 910463-68-2). Produced using a next-generation fully synthetic process that integrates solid-phase and liquid-phase synthesis-distinct from traditional semi-fermentation methods-our Semaglutide achieves an overall purity exceeding 99.5%. Individual impurities are strictly controlled below 0.1%, and the product features extremely low endotoxin levels, is pyrogen-free, and contains no animal-derived components. Key advantages include exceptional batch-to-batch consistency, stability against degradation and aggregation, and suitability for both long-term formulation development and large-scale production. We offer high-purity Semaglutide (99.5%+) with low impurity and endotoxin levels, consistent quality, and ample stock; we also support third-party testing and custom specifications. This long-acting GLP-1 API offers dual benefits for blood glucose control and weight loss, matches the quality of the originator drug, and provides a significant cost advantage, making it ideal for formulation R&D and mass production.
The Effects of Semaglutide Raw Powder
1. Blood Sugar-Lowering Effects
- Glucose-dependent insulin secretion: Stimulates secretion only when blood sugar is high, minimizing the risk of hypoglycemia.
- Inhibition of glucagon: Reduces hepatic glucose release, stabilizing postprandial blood sugar levels.
- Mild delay in gastric emptying: Slows carbohydrate absorption for more stable blood sugar control.
- Improved insulin sensitivity: Long-term use can alleviate insulin resistance.
2. Weight Loss Effects
- Central appetite suppression: Acts on the hypothalamus to significantly reduce hunger and food intake.
- Significant delay in gastric emptying: Promotes a strong, sustained sense of fullness, naturally leading to reduced food intake.
- Regulation of lipid metabolism: Promotes the browning of white adipose tissue and increases basal energy expenditure.
- Long-acting and stable: Half-life of approximately 7 days; once-weekly dosing ensures high patient compliance.
3. Comprehensive Metabolic Improvement
Improves fatty liver conditions and lowers liver enzymes; addresses blood sugar, body weight, blood pressure, and blood lipids simultaneously.
Test Results Shown Below
Advantages and Characteristics of Semaglutide Raw Material Powder
Key Characteristics
High Purity
Purity ≥99% (HPLC); individual impurity <0.1%; total impurities <0.5%; meets EP/USP standards.
01
Physical Properties
White to off-white powder; hygroscopic; good water solubility (>100 g/L at pH ≥7).
02
Long-acting Molecular Structure
Modified with a C18 fatty acid chain; half-life ≈7 days; suitable for once-weekly administration.
03
Animal-free
Fully synthetic/recombinant process; free from viral contamination and animal-derived residues.
04
High Stability
Resistant to DPP-4 enzyme degradation; stable for 18–24 months at -15°C; minimal batch-to-batch variation.
05
Key Advantages
Potent Blood Glucose Reduction & Weight Loss
Blood Glucose: HbA1c reduction of 1.8%–2.0%; fasting blood glucose reduction of over 40%.
Weight Loss: Average weight loss of 15%–18%, outperforming similar GLP-1 products.
High Production Capacity & Cost Efficiency
Batch sizes of 10–100 kg; annual capacity of 5–10 metric tons.
Fully synthetic process reduces costs by 20%–40% and ensures stable supply.
Export Compliance
COA, MSDS, DMF, and GMP documentation available.
Compliant with FDA and EU GMP standards; supports global registration.
High Safety Profile
Sterile, pyrogen-free, controlled impurity levels, and low side effects.
Product Specifications
| Basic Information | |
| Name |
Semaglutide raw powder |
| CAS Number |
910463-68-2 |
| Molecular formula |
C₁₈₇H₂₉₁N₄₅O₅₉ |
| Molecular weight |
4113.64 g/mol |
| Molecular structure diagram |  |
| Appearance | White to off-white crystalline powder |
| Purity | ≥99.5% (HPLC) |
| Grade | Ph. Eur./USP grade; complies with GMP standards for active pharmaceutical ingredients (APIs). |
| Quality Specifications | |
| Purity |
≥99.5% |
| Single-hetero | ≤0.1% |
| General Merchandise | ≤0.5% |
| Peptide content | ≥90% |
| Endotoxin | ≤10 EU/mg |
| Loss on drying | ≤5.0% |
| Residue on ignition | ≤0.5% |
| Heavy metal | ≤10 ppm |
| Physicochemical Properties & Storage Requirements | |
| Solubility | Soluble in water and polar organic solvents. |
| Storage conditions | Long-term: -15°C to -20°C; short-term: 2°C to 8°C |
| Shelf life | 24 months |
Packaging and Delivery
Packaging Specifications
Bulk packaging: 25kg standard export-grade cardboard drums, kraft paper drums, or plastic drums-sturdy, pressure-resistant, and deformation-resistant.
Fully double-sealed to prevent moisture absorption, caking, leakage, and contamination.
Delivery Channel
Supports delivery via DHL, FedEx, UPS, EMS, as well as sea, air, and multi-channel shipping options;
Reliable freight forwarding partnerships enable end-to-end tracking of logistics, customs clearance, and release status, with timely updates provided to the customer.
Payment methods: Wire transfer (T/T), Western Union, MoneyGram, and Letter of Credit (L/C).
Delivery Period
Standard stock items: Shipped within 24–48 hours of payment confirmation.
Customized repackaging/special specifications: Shipment arranged within 3–7 business days.
High-volume orders during peak seasons are scheduled in advance to ensure on-time delivery.
After-sales Guarantee
Pre-sales service
Technical Consultation: A professional team provides product specifications, application solutions, and compliance guidance, while addressing inquiries related to R&D and production.
Sample Assurance: Small samples are available for testing prior to placing an order (shipping costs borne by the customer); orders may be cancelled unconditionally if the sample specifications do not match those of the bulk shipment.
Pre-sale service
Order Tracking: Real-time synchronization of production progress, shipment status, and logistics information, accessible to customers at any time.
Quality Communication: Re-inspection and verification of each batch prior to shipment, with timely feedback on test results to ensure product quality.
Customization: Adjustment of purity, packaging, and documentation based on customer needs to meet specific order requirements.
After-sales service
Quality Assurance: Free returns and exchanges are available for any quality issues within 7 days of delivery, with shipping costs covered by us.
Technical Support: Ongoing technical guidance provided, including formula optimization, process adjustments, and compliance declarations.
Long-term Partnership: Establishment of customer profiles to provide priority supply, preferential pricing, and dedicated service, ensuring a stable, long-term partnership.
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