Synephrine Hydrochloride raw material powder (CAS: 5985-28-4)-also known as Synephrine HCl or Phenylephrine HCl-is a high-purity alkaloid derived from *Citrus aurantium* (bitter orange). It appears as a white, highly crystalline powder with excellent water solubility and stability. As a leading, safe ingredient for metabolic fat loss, Synephrine Hydrochloride effectively boosts basal metabolism, accelerates lipolysis, and aids in body shaping and slimming. It offers a gentle profile that does not spike heart rate, making it a popular, high-quality alternative to traditional stimulant-based fat-loss ingredients in the weight management and sports nutrition sectors.
Product Introduction
Synephrine Hydrochloride (also known as *p*-synephrine HCl or *p*-hydroxy-phenylephrine HCl) is a highly active alkaloid ingredient extracted and refined from *Fructus Aurantii Immaturus* (immature bitter orange fruit). Appearing as a white crystalline powder, it is characterized by high purity, excellent water solubility, and strong stability. It is currently a leading, safe ingredient in the international market for metabolic fat loss and sports nutrition.
This product works by selectively activating β3-adrenergic receptors in human adipocytes, thereby accelerating lipolysis, boosting basal metabolic rate, and promoting calorie expenditure. It effectively reduces the accumulation of subcutaneous and visceral fat, aiding in weight management and body shaping. Compared to traditional fat-loss ingredients, Synephrine Hydrochloride acts gently; it does not stimulate heart rate or cause significant stimulant-like side effects, making it suitable for long-term dietary supplementation. It is a popular, key ingredient in overseas fat-loss supplements and fitness products.
Produced using advanced purification and crystallization processes, our Synephrine Hydrochloride offers batch-to-batch consistency, ultra-low impurity levels, a fine powder texture, and excellent solubility. It is suitable for use in capsules, tablets, meal replacement powders, solid beverage mixes, sports nutrition powders, and more.
Synephrine Hydrochloride (Characteristics, Core Advantages, and Functions)
1. Optimized Salt-Form Structure for Superior Storage and Transport Stability
Unlike free-base synephrine, the hydrochloride salt structure significantly enhances the powder's resistance to deliquescence. It remains free of caking and retains its potency even after months of storage or exposure to the high-humidity, high-temperature conditions of transoceanic shipping containers, making it ideal for long-cycle global inventory stocking. The powder features a uniform crystalline structure and consistent particle size; a proprietary sieving process ensures dust-free handling and prevents clogging, making it perfectly suited for continuous automated production lines for tablets and capsules.
2. Targeted Botanical Extraction and Purification for Ingredient Purity
Derived through the targeted extraction and enrichment of immature *Citrus aurantium* (bitter orange) fruit, this process eschews total chemical synthesis in favor of isolating specific target alkaloid components while strictly controlling pesticide residues and exogenous impurities. A wide range of specifications is available-from 5% extracts to 98% high-purity crystals-all standardized via HPLC analysis. Each batch comes with a fully traceable chromatogram, meeting the rigorous audit standards for natural dietary supplement ingredients in overseas markets.

1. Safety and Differentiation in the Fat-Loss Sector
It serves as a safe alternative to stimulant-based fat-loss ingredients like caffeine and ephedrine. By selectively modulating metabolic thermogenesis, it avoids adverse effects such as tachycardia, insomnia, and nervous system overstimulation or dependency. It offers high tolerability for long-term dietary supplementation, making it a preferred choice for compliant ingredient replacement among Western fat-loss supplement brands and facilitating higher product registration approval rates.
2. Closed-Loop Quality Control and Reliable Supply
We maintain end-to-end closed-loop control-spanning raw fruit procurement, extraction and crystallization, to final product packaging-with a monthly production capacity of 10,000 tons. Production can be scheduled immediately for orders ranging from small samples to full container loads (tonnage scale). Each batch comes with an independent Certificate of Analysis (COA), microbiological test report, and Material Safety Data Sheet (MSDS), providing a one-stop solution for international customs clearance and brand registration documentation reviews.

1. Targeted breakdown of stored fat for body contouring and fat loss
By binding to adipocyte β3-receptors and activating lipolytic enzymes, the process mobilizes stored subcutaneous and visceral triglycerides, breaking them down into free fatty acids. These are then converted via mitochondrial oxidation into usable thermal energy. This approach targets the root cause of fat accumulation-specifically reducing excess fat in the waist, abdomen, and limbs-rather than simply causing weight loss through water loss.
2. Sustained boost in resting metabolism to build a "lean" physique
It induces a mild thermogenic effect, slightly raising the basal metabolic rate. This ensures a steady increase in calorie expenditure even during periods of rest, while inhibiting the conversion and storage of excess sugars and carbohydrates from meals as fat. When combined with dietary management, this leads to consistently improved weight loss efficiency.

Core Basic Parameters Table
| Generic Name | Synephrine Hydrochloride |
| CAS No. | 5985-28-4 |
| Chemical Formula | C₉H₁₃NO₂·HCl |
| Molecular Weight | 203.67 |
| Appearance | White crystalline powder |
| Odor | Odorless |
| Solubility | Highly soluble in water and methanol; slightly soluble in ethanol; practically insoluble in oils/fats and chloroform |
| Purity Specification | Plant extract grade: 5%, 30%, 60% High-purity crystalline grade: 98% (HPLC analysis) |
| Test Method | High-Performance Liquid Chromatography (HPLC) |
| pH (Aqueous Solution) | 4.0 – 6.0 |
| Moisture Content | ≤0.5% |
| Residue on Ignition | ≤0.1% |
| Heavy Metal Limits | Lead (Pb) ≤10 ppm Arsenic (As) ≤2 ppm Cadmium (Cd) ≤1 ppm Mercury (Hg) ≤0.1 ppm |
| Microbiological Limits | Total bacterial count ≤1000 CFU/g Molds and yeasts ≤100 CFU/g Escherichia coli, Salmonella: Not detected |
| Storage Conditions | Store in a sealed container in a cool, dry place away from light; ambient temperature ≤25°C; keep away from moisture and high heat |
| Shelf Life | 24 months (unopened original packaging) |
| Standard Packaging | 25 kg/food-grade kraft paper drum (with double-layer PE vacuum bags inside); small samples |
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